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Test ID FNEU Neurotransmitter Metabolites (5HIAA, HVA, 3OMD) (CSF)

Reporting Name

Neurotransmitter Metabolites

Performing Laboratory

Medical Neurogenetics, LLC

Specimen Type


Specimen Required

Medical Neurogenetics collection kit (MML Supply T657) required.

Each collection kit contains 5 microcentrifuge tubes.



1)     CSF should be collected from the first drop into the tubes in the  numbered order. Fill each tube to the marked line with the required volumes

Tube 1: 0.5 mL

Tube 2: 1.0  mL

Tube 3: 1.0 mL (contains antioxidants necessary to protect the sample integrity)

Tube 4: 1.0 mL

Tube 5: 1.0  mL

-       If sample's not blood contaminated, the tubes should be placed on dry ice at bedside

-       If sample's are blood contaminated, the tubes should immediately be centrifuged (prior to freezing) and the clear CSF transferred to new similarly labeled tubes, then frozen

-       Store samples at -80 until they can be shipped

2)     Complete Medical Neurogenetics, LLC request form. Include test required, sample date and date of birth.

3)     Label tubes with patient name and ID number, leaving the tube number viewable.

4)     Place samples inside a specimen transport bag and the Medical Neurogenetics, LLC request form inside the pouch of the transport bag.

5)     Ship samples frozen on dry ice.

Specimen Minimum Volume

4.5 mL

Specimen Stability Information

Specimen Type Temperature Time
CSF Frozen

Reference Values

Age           5HIAA              HVA             3-O-MD

(years)      (nmol/L)           (nmol/L)        (nmol/L)


0-0.2        208-1159           337-1299         <300

0.2-0.5      179-711            450-1132         <300

0.5-2.0      129-520            294-1115         <300

2.0-5.0       74-345             233-928          <150

5.0-10        66-338             218-852          <100

10-15         67-189             167-563          <100

Adults        67-140             145-324          <100


Interpretation performed by Keith Hyland, Ph.D.


Note: If test results are inconsistent with the clinical presentation, please call our laboratory to discuss the case and/or submit a second sample for confirmatory testing.


DISCLAIMER required by the FDA for high complexity clinical laboratories: This test  was developed and its performance characteristics determined by Medical Neurogenetics, LCC. It has not been cleared or approved by the U.S. FDA.

Day(s) and Time(s) Performed

Monday through Friday

CPT Code Information




LOINC Code Information

Test ID Test Order Name Order LOINC Value
FNEU Neurotransmitter Metabolites In Process


Result ID Test Result Name Result LOINC Value
Z0852 5-Hydroxyindoleacetic acid 47544-2
Z0849 Homovanillic acid 40846-8
Z0850 3-O-methyldopa 34596-7
Z0851 Interpretation: In Process

Reject Due To

Specimens other than

CSF in special collection kit (MML supply T657)

Anticoagulants other than





Warm reject; Cold reject





Method Name


Secondary ID