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Test ID BLOD1807 CD107a Mobilization (NK Cell Degranulation)

Important Note

Time Sensitive Test:

Specimen must be collected after 0900 and received at Sanford Referrals by noon on the day of collection, Monday through Wednesday. 

Do not collect Thursday through Sunday or on the day prior to a holiday. 

Please contact Sanford Laboratories Client Support if a holiday falls during the week for increased testing restrictions.

**For counts below 0.20 K/mcL, consider waiting until count increases.**

**For counts above 1.00 K/mcL, draw 5 mL. It is not recommended to draw less than 5 mL.**

To determine draw volume, refer to Custom Volumes by Absolute Lymphocyte Count

Synonym

HLH, NK Cell Degranulation, CD107a NK Cell

Ordering Guidance

The CD107a Mobilization assay evaluates the cytotoxic machinery of NK cells by assessing degranulation via flow cytometry. Upon degranulation, CD107a is expressed on the NK cell surface and can be detected with antibody staining. This assay can help identify or assess variants in genes such as UNC13D, STXBP2, STX11, LYST, and RAB27A which cause defects in degranulation.

Specimen Type/Requirements

Dark Green top (Sodium heparin w/out gel) tube - Whole blood (Preferred)

Yellow top (ACD-A or ACD-B) tube - Whole blood 

 

**Multiple tubes may be required**

Specimen Volume

Refer to Custom Volumes by ALC for specific draw volumes

Stability/Transport

 Room Temperature     24 hours        Preferred for Transport   
 Refrigerated           Not Acceptable     
 Frozen  Not Acceptable        

Performed Test Frequency

Monday - Thursday

Report Available

3 days

Methodology

Flow Cytometry

Performing Lab

Cincinnati Children's

CPT

88184, 88185 x 3, 88187, 86352

Interface Build Information

 Result Code     Result Code Description   
 8063  See Scanned Report