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Test ID BLOD0177 Glucagon, Plasma

Reporting Name

Glucagon, P

Useful For

Diagnosis and follow-up of glucagonomas and other glucagon-producing tumors

 

Assessing diabetic patients with problematic hyper- or hypoglycemic episodes (extremely limited utility)

 

Glucagon is routinely measured along with serum glucose, insulin, and C-peptide levels, during the mixed-meal test employed in the diagnostic workup of suspected postprandial hypoglycemia. However, it plays only a minor role in the interpretation of this test.

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Plasma EDTA


Specimen Required


Collection Container/Tube: Lavender top (EDTA)

Submission Container/Tube: Plastic vial

Specimen Volume: 2 mL

Collection Instructions:

1. Fasting

2. Prechill tube at 4° C before drawing the specimen.

3. Draw the prechilled tube, and process as follows:

a. After drawing specimen, chill tube in wet ice for 10 minutes.

b. Centrifuge in a refrigerated centrifuge or in chilled centrifuge cup.

c. Immediately after centrifugation, remove plasma, place in a plastic transport vial (T465), and freeze.


Specimen Minimum Volume

0.45 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma EDTA Frozen 90 days

Reference Values

≤6 hours: 100-650 pg/mL

1-2 days: 70-450 pg/mL

2-4 days: 100-650 pg/mL

4-14 days: declining gradually to adult levels

>14 days: ≤80 pg/mL (range based on 95% confidence limits)

Glucagon levels are inversely related to blood glucose levels at all ages. This is particularly pronounced at birth and shortly thereafter, until regular feeding patterns are established. This explains the higher levels immediately after birth, which then first fall as the glucagon release mobilizes the infant's glucose stores, then rise again as stores are depleted, finally normalizing towards adult levels as regular feeding patterns are established.

Day(s) and Time(s) Performed

Monday, Thursday; 10 a.m.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

82943

LOINC Code Information

Test ID Test Order Name Order LOINC Value
GLP Glucagon, P 2338-2

 

Result ID Test Result Name Result LOINC Value
9358 Glucagon, P 2338-2

Reject Due To

Hemolysis

Mild OK; Gross reject

Lipemia

Mild OK; Gross OK

Icterus

Mild OK; Gross OK

Other

NA

Method Name

Immunoassay Following Extraction